The 280 Ackley Improved is cartridge that can be used for multiple species around the world.  It handles lighter 139 grain bullets as well as heavy 175 grain bullets.  The bullet offerings for the 280 Ackley Improved will cover a wide range of applications.  The 175 grain Hornady ELD-X is an aerodynamic effective long-range option.  If you are looking for a tough controlled expansion bullet for larger animals or close quarters hunting, the 175 grain Nosler Partition or 175 grain Swift A-Frame are both great options.  If you want a great do all bullet that will handle close quarters shots or long-range engagements, the monolithic bullets from Barnes and Hornady are great options.